Description

Ivabradine Hydrochloride is a highly selective and specific inhibitor of the cardiac pacemaker If current, used to lower heart rate. This active pharmaceutical ingredient (API) is critical for the formulation of cardiovascular medications that treat chronic heart failure and stable angina pectoris. It is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of cardioprotective drugs.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for the treatment of chronic heart failure and angina.
• Cardiovascular Drug Formulation: Used in the development and manufacturing of tablets and other oral solid dosage forms.
• Clinical Research: Serves as a reference standard and key material in pharmacological studies and clinical trials.
• Generic Drug Manufacturing: Essential for companies producing bioequivalent versions of branded ivabradine medications.
• Preclinical Development: Utilized in animal studies to investigate heart rate reduction and related therapeutic effects.

Basic Information

Product Name	Ivabradine Hydrochloride
CAS No.	148849-67-6
Molecular Formula	C27H36N2O5•HCl
Molecular Weight	505.05 g/mol
Synonyms	Ivabradine HCl; S 16257; Procoralan (Trade Name); Coralan (Trade Name); (3-{3-[(7S)-3,4-Dimethoxy-7,8,9,10-tetrahydro-6,9-methanobenzocycloocten-11(6H)-yl]propyl}-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one) Hydrochloride; S-16257-2
EINECS	Contact for details

Quality Control

Our Ivabradine Hydrochloride is manufactured under strict quality systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical use, with specifications aligning with major pharmacopoeial guidelines. A comprehensive Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.