Description

Levosimendan CAS NO 141505-33-1 is a calcium sensitizer and vasodilator belonging to the pyridazinone-dinitrile class of compounds. It is a critical active pharmaceutical ingredient (API) primarily used in the treatment of acute decompensated heart failure. This product is essential for pharmaceutical manufacturers and research institutions developing cardiology medications. Its mechanism of action, which increases cardiac contractility without significantly raising myocardial oxygen demand, makes it a valuable therapeutic agent.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable formulations for acute heart failure.
• Cardiology Research: A key reference standard and investigational compound in cardiovascular disease studies.
• Drug Formulation Development: Used in R&D for developing new dosage forms, including lyophilized powders for injection.
• Clinical Trial Material (CTM): Supplied as a high-purity compound for Phase I-III clinical trials in heart failure therapy.
• Pharmacology Studies: Employed in in-vitro and in-vivo models to study myocardial calcium sensitivity and hemodynamics.
• Generic Drug Manufacturing: Sourced by generic pharmaceutical companies for the production of approved therapeutic equivalents.

Basic Information

Product Name	Levosimendan
CAS No.	141505-33-1
Molecular Formula	C14H12N6O
Molecular Weight	280.29 g/mol
Synonyms	(-)-[[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile; (R)-[[4-(1,4,5,6-Tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]hydrazono]propanedinitrile; Simdax; OR-1259; Levosimendanum; (R)-Levosimendan; (-)-Levosimendan
EINECS	Contact for details

Quality Control

Our Levosimendan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide full traceability and support regulatory filings with comprehensive documentation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%
Specific Rotation	-88° to -92° (c=1 in methanol)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.