Description

2-Methyl-3-Trifluoromethyl-Phenylboronic Acid is a specialized organoboron compound that serves as a crucial building block in modern synthetic chemistry. Its value lies in enabling the precise construction of complex molecular architectures, particularly those containing the trifluoromethyl group, which is highly sought-after for its ability to modulate the physical and biological properties of target molecules. This boronic acid is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients through efficient cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those requiring a trifluoromethylated biphenyl or aryl scaffold.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances bioavailability and stability.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where fluorinated aromatic units improve charge transport properties.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology Probes: Utilized to tag or modify biomolecules for study, leveraging the boronic acid group's affinity for diols.
• Custom Synthesis and Contract Manufacturing: A vital reagent for fine chemical suppliers and CROs/CMOs offering bespoke synthesis services for client projects.

Basic Information

Product Name	2-Methyl-3-Trifluoromethyl-Phenylboronic Acid
CAS No.	947533-86-0
Molecular Formula	C9H8BF3O2
Molecular Weight	216.0 g/mol
Synonyms	(2-Methyl-3-(trifluoromethyl)phenyl)boronic acid; 3-Trifluoromethyl-2-methylbenzeneboronic acid; 2-Methyl-3-trifluoromethylbenzeneboronic acid; Boronic acid, B-[2-methyl-3-(trifluoromethyl)phenyl]-; 2-Methyl-α,α,α-trifluoro-m-tolueneboronic acid
EINECS	Contact for details

Quality Control

Our 2-Methyl-3-Trifluoromethyl-Phenylboronic Acid is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and 1H/11B/19F NMR for structural confirmation, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.