Description

5-Trifluoromethyl-Pyridine-3-Boronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. This compound is a key reagent in the Suzuki-Miyaura cross-coupling reaction, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing trifluoromethylpyridine motifs.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides that require specific fluorinated heterocyclic structures.
• Material Science Research: Employed in the creation of novel organic electronic materials, ligands for catalysis, and specialty polymers.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid partner for palladium-catalyzed carbon-carbon bond formation with various aryl and heteroaryl halides.
• Chemical Biology & Medicinal Chemistry: Facilitates the rapid exploration of structure-activity relationships (SAR) in drug discovery programs through efficient library synthesis.

Basic Information

Product Name	5-Trifluoromethyl-Pyridine-3-Boronic Acid
CAS No.	947533-51-9
Molecular Formula	C6H5BF3NO2
Molecular Weight	190.92 g/mol
Synonyms	(5-(Trifluoromethyl)pyridin-3-yl)boronic acid; 3-Pyridineboronic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)-3-pyridinylboronic Acid; 5-Trifluoromethyl-3-pyridylboronic Acid; 3-Borono-5-(trifluoromethyl)pyridine; 5-Trifluoromethylpyridine-3-boronic Acid Pinacol Ester (common derivative)
EINECS	Contact for details

Quality Control

Our 5-Trifluoromethyl-Pyridine-3-Boronic Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality system is designed to meet the stringent requirements of advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.