Description

Docosahexaenoyl Ethanolamide-D4 is a deuterated analog of the endogenous lipid mediator docosahexaenoyl ethanolamide (DHEA), a specialized pro-resolving mediator (SPM) derived from docosahexaenoic acid (DHA). This stable isotope-labeled compound is essential for precise quantitative analysis in biomedical research, enabling accurate pharmacokinetic and metabolic studies. It is primarily utilized by researchers and analytical laboratories in the pharmaceutical, nutraceutical, and life science sectors for use as an internal standard in mass spectrometry.

Application

• Internal Standard for LC-MS/MS: Critical for the accurate quantification of endogenous DHEA and related lipid mediators in complex biological matrices like plasma, serum, and tissue homogenates.
• Metabolic Pathway Research: Used to trace and elucidate the biosynthesis, distribution, and degradation pathways of specialized pro-resolving mediators (SPMs) in inflammation resolution studies.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables precise measurement of drug effects on the endocannabinoid and SPM systems in preclinical and clinical research.
• Biomarker Discovery and Validation: Supports the development of robust analytical assays to identify and validate DHEA as a potential biomarker for inflammatory and metabolic diseases.
• Quality Control in Analytical Laboratories: Serves as a reference standard to ensure the accuracy and reproducibility of analytical methods in contract research organizations (CROs) and diagnostic labs.
• Nutritional and Clinical Research: Facilitates studies investigating the impact of ω-3 fatty acid supplementation on the production of bioactive lipid mediators in human health.

Basic Information

Product Name	Docosahexaenoyl Ethanolamide-D4
CAS No.	946524-43-2
Molecular Formula	C24H31D4NO3
Molecular Weight	~ 381.56 g/mol
Synonyms	DHEA-d4; Docosahexaenoylethanolamide-d4; 4,4,5,5-D4-Docosahexaenoyl Ethanolamide; N-Docosahexaenoyl Ethanolamine-d4; Deuterated DHEA; (4Z,7Z,10Z,13Z,16Z,19Z)-4,4,5,5-tetradeuterio-N-(2-hydroxyethyl)docosa-4,7,10,13,16,19-hexaenamide; DHA-EA-d4; Synaptamide-d4
EINECS	Contact for details

Quality Control

Our Docosahexaenoyl Ethanolamide-D4 is produced and handled under strict quality protocols to ensure the highest standards of isotopic purity and chemical integrity, essential for reliable analytical results. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity confirmation via advanced spectroscopic techniques. We adhere to GMP principles for laboratory chemicals, ensuring traceability and consistency for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. Store in a cool, dry, and well-ventilated area away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (Assay)	≥ 97%
Solubility	Soluble in ethanol, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.