Description

Acetylcholine Iodide, [Acetyl-1-14C] is a radiolabeled derivative of the essential neurotransmitter acetylcholine, where the acetyl group is specifically tagged with carbon-14 at the 1-position. This compound is critical for conducting high-sensitivity tracer studies in neurochemical and pharmacological research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and contract research organizations (CROs) investigating cholinergic systems, receptor binding, enzyme kinetics, and metabolic pathways.

Application

• Neuropharmacology Research: As a tracer for studying the synthesis, release, reuptake, and degradation of acetylcholine in vitro and in vivo.
• Enzyme Activity Assays: Used as a substrate in radiometric assays for acetylcholinesterase (AChE) and choline acetyltransferase (ChAT) activity.
• Receptor Binding Studies: Employed in competitive binding and autoradiography experiments to characterize muscarinic and nicotinic acetylcholine receptors.
• Metabolic Pathway Tracing: Enables the detailed mapping of cholinergic metabolic fluxes and the fate of the acetyl moiety in biological systems.
• Drug Discovery & Development: Facilitates the screening and mechanistic evaluation of new compounds targeting the cholinergic system for neurological disorders.
• Biochemical Synthesis: Serves as a labeled precursor for the synthesis of other radiolabeled cholinergic compounds or probes.

Basic Information

Product Name	Acetylcholine Iodide, [Acetyl-1-14C]
CAS No.	16238-80-5
Molecular Formula	C7H16INO2 * ([14C]CH3CO-)
Molecular Weight	~273.11 g/mol (unlabeled)
Synonyms	1-Acetoxy-N,N,N-trimethylethanaminium Iodide, [acetyl-1-14C]; (2-Acetoxyethyl)trimethylammonium Iodide-1-14C; ACh iodide-14C; [1-14C]Acetylcholine Iodide; Radiolabeled Acetylcholine Iodide; Carbon-14 Labeled ACh; Choline acetate ester iodide (labeled)
EINECS	Contact for details

Quality Control

Every batch of Acetylcholine Iodide, [Acetyl-1-14C] is manufactured and analyzed under strict quality control protocols to ensure high chemical and radiochemical purity, specific activity, and stability. Our quality system ensures traceability and compliance with relevant guidelines for handling radioactive materials. Certificates of Analysis (COA) detailing purity (HPLC), specific activity (MBq/mmol or mCi/mmol), radiochemical identity, and solvent composition are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store frozen (at or below -20°C) in the original solvent as supplied. Due to its hygroscopic (moisture-sensitive) nature, containers should be allowed to reach room temperature before opening to prevent condensation. For long-term stability, store under an inert atmosphere. Handle and dispose of in accordance with all applicable local, national, and international radiation safety regulations.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (HPLC, TLC)	Conforms to reference standard
Assay (HPLC)	≥ 95% (Chemical Purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	1.85 - 2.22 GBq/mmol (50 - 60 mCi/mmol)
Solvent	Ethanol:Water (9:1) or as specified
Concentration	~1.0 mCi/mL (37 MBq/mL) or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.