Description

Pregnenolone Sulfate Sodium Salt is a key neurosteroid and a major metabolite of pregnenolone, serving as a potent negative allosteric modulator of the GABAA receptor. This activity makes it a critical research tool for studying neurological pathways related to memory, learning, and mood regulation. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for preclinical studies and reference standard applications.

Application

• Neurological Research: Used as a reference standard and active agent in studies of GABAA receptor function, neurosteroid signaling, and synaptic plasticity.
• Pharmacological Studies: Employed in the investigation of cognitive enhancers, anxiolytics, and treatments for neurodegenerative conditions.
• Biochemical Assay Development: Serves as a critical component in developing and validating assays for neurosteroid detection and quantification.
• Reference Standard: Used in analytical laboratories for HPLC, LC-MS, and other chromatographic methods to ensure accuracy and quality control.
• Academic & Institutional Research: Fundamental for basic science research in universities and research institutes exploring endocrinology and neuroscience.

Basic Information

Product Name	Pregnenolone Sulfate Sodium Salt
CAS No.	1852-38-6
Molecular Formula	C21H31NaO5S
Molecular Weight	418.52 g/mol
Synonyms	Pregnenolone Sodium Sulfate; 3β-Hydroxy-5-pregnen-20-one 3-sulfate sodium salt; Sodium Pregn-5-en-3β-ol-20-one 3-sulfate; 5-Pregnen-3β-ol-20-one 3-sulfate sodium salt; Pregnenolone 3-sulfate sodium; Pregnenolone sulphate sodium salt; (3β)-3-(Sulfooxy)pregn-5-en-20-one sodium salt
EINECS	217-445-5

Quality Control

Our Pregnenolone Sulfate Sodium Salt is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and other validated methods to ensure it meets high-purity standards suitable for research applications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment when possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.