Description

1,3,5[10]-Estratriene-3,17Beta-Diol 3-Glucuronide Sodium Salt is a high-purity conjugated metabolite of estradiol, specifically the sodium salt of its 3-O-glucuronide. This compound is of critical importance as a reference standard and analytical reagent for the precise quantification and metabolic profiling of endogenous estrogens. It is primarily required by pharmaceutical R&D laboratories, clinical diagnostic manufacturers, and academic research institutions focused on endocrinology, hormone metabolism, and bioanalytical method development.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the assay and impurity profiling of steroid-based pharmaceuticals and biologics.
• Clinical Diagnostics: Calibration and quality control of immunoassays and LC-MS/MS systems used to measure estrogen metabolites in serum, plasma, and urine for diagnostic purposes.
• Metabolomics & Biomarker Research: A key analyte in studies investigating estrogen metabolism pathways, their relation to health and disease states, and the discovery of novel biomarkers.
• Doping Control Analysis: Used by anti-doping laboratories to accurately identify and confirm the presence of endogenous anabolic steroid metabolites in athletes' samples.
• Toxicology & Pharmacokinetics: Employed in ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand the conjugation and elimination pathways of steroidal compounds.
• Biochemical Reagent: Serves as a substrate or inhibitor in enzymatic studies related to glucuronidation (UGT enzymes) and steroid hormone metabolism.

Basic Information

Product Name	1,3,5[10]-Estratriene-3,17Beta-Diol 3-Glucuronide Sodium Salt
CAS No.	14982-12-8
Molecular Formula	C24H31NaO8
Molecular Weight	470.49 g/mol
Synonyms	Estradiol 3-Glucuronide Sodium Salt; 17β-Estradiol 3-Glucuronide Sodium Salt; E2-3G Sodium Salt; Sodium Estradiol 3-β-D-Glucuronide; 3-Hydroxyestra-1,3,5(10)-trien-17β-yl β-D-Glucopyranosiduronic Acid Sodium Salt; Estra-1,3,5(10)-triene-3,17β-diol (17β)-, 3-(β-D-Glucopyranosiduronate) Sodium Salt; NSC 113492
EINECS	Contact for details

Quality Control

Every batch of our 1,3,5[10]-Estratriene-3,17Beta-Diol 3-Glucuronide Sodium Salt is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure it meets the stringent requirements for use as a high-purity reference material. Certificates of Analysis (COA) detailing identity, purity (by HPLC), and specific tests are supplied with each shipment. Our quality protocols are designed to support compliance with GMP/GLP principles for research and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤5.0%
Residue on Ignition	≤1.0%
Specific Rotation	Contact for details
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.