Description

Aldosterone-1,2-3H is a high-specific-activity, tritium-labeled derivative of the essential mineralocorticoid hormone aldosterone. This radiochemical is critical for high-sensitivity detection and quantification in advanced research applications, enabling precise metabolic and receptor-binding studies. It is primarily utilized by pharmaceutical R&D teams, clinical research organizations, and academic institutions specializing in endocrinology, hypertension research, and steroid hormone analysis.

Application

• Receptor Binding Assays (RBA): Used as a tracer ligand for studying the affinity and density of mineralocorticoid receptors (MR) in competitive binding experiments.
• Metabolic Pathway Tracing: Enables the detailed investigation of aldosterone biosynthesis, metabolism, and clearance rates in in vitro and ex vivo systems.
• Drug Discovery & Development: Serves as a key tool for screening and characterizing novel MR antagonists and modulators for cardiovascular and renal diseases.
• Diagnostic Assay Development: Employed in the development and calibration of radioimmunoassays (RIA) and other immunoassays for aldosterone quantification.
• Autoradiography: Used for the spatial localization and visualization of MR distribution in tissue sections.
• Absorption, Distribution, Metabolism, and Excretion (ADME) Studies: Facilitates the tracking of aldosterone's pharmacokinetic profile in preclinical models.

Basic Information

Product Name	Aldosterone-1,2-3H
CAS No.	1173-06-4
Molecular Formula	C21H28O5 (³H labeled)
Molecular Weight	~364.4 g/mol (³H labeled)
Synonyms	11β,21-Dihydroxy-3,20-dioxopregn-4-en-18-al (1,2-³H); [1,2-³H]Aldosterone; 11β,21-Dihydroxy-18-oxopregn-4-ene-3,20-dione-1,2-³H; 18-Oxocorticosterone-1,2-³H; Tritiated Aldosterone; ³H-Aldosterone; Electrocorrin; Aldocorten.
EINECS	Contact for details

Quality Control

Every batch of Aldosterone-1,2-3H is manufactured and analyzed under strict quality systems. Radiochemical purity and specific activity are determined via validated methods including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific results for identity, purity, activity, and solvent composition to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the solution at or below -20°C. The product is strictly light-sensitive (protect from all light exposure). Allow the product to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Conforms to reference standard
Specific Activity	Contact for details (Typical range: 40-80 Ci/mmol)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 98%
Solvent	Ethanol or Toluene/Ethanol mixture
Concentration	1.0 mCi/mL (Contact for other concentrations)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.