Description

Glucose, L-, [1-14C] CAS NO 10326-73-5 is a high-purity, carbon-14 labeled isotopologue of L-glucose, a non-naturally occurring enantiomer of the common sugar. This product is specifically designed for advanced research applications requiring precise metabolic and biochemical pathway tracing. It is an essential tool for scientists in pharmaceutical development, metabolic disease research, and biochemistry. The compound is supplied with a high specific activity, ensuring reliable detection and accurate results in sensitive analytical techniques.

Application

• Metabolic Pathway Tracing: Used as a radiolabeled tracer to study the uptake, distribution, and metabolism of glucose enantiomers in biological systems, particularly in research on carbohydrate metabolism and diabetes.
• Pharmaceutical R&D: Employed in the development and testing of new drugs, especially those targeting glucose transporters (GLUTs) or metabolic enzymes, to understand mechanism of action and pharmacokinetics.
• Biochemical Research: Serves as a substrate in enzymatic assays to study the specificity and kinetics of enzymes like hexokinase and glucose oxidase towards different sugar stereoisomers.
• Nutritional Science Studies: Applied in research investigating the differential metabolic effects of D- and L-sugars, contributing to studies on artificial sweeteners and low-calorie food ingredients.
• Diagnostic Agent Development: Acts as a precursor in the synthesis of potential Positron Emission Tomography (PET) imaging agents for researching neurological disorders and cancer metabolism.

Basic Information

Product Name	Glucose, L-, [1-14C]
CAS No.	10326-73-5
Molecular Formula	C6H12O6 (with 14C at position 1)
Molecular Weight	~180.16 g/mol (exact mass depends on 14C incorporation)
Synonyms	L-Glucose-1-14C; (3R,4S,5S,6R)-6-(Hydroxymethyl)oxane-2,3,4,5-tetrol-1-14C; 1-14C-L-Glucose; L-(-)-Glucose-1-14C; Carbon-14 labeled L-Glucose; [1-14C]-L-Glucose; Radiolabeled L-Glucose
EINECS	Contact for details

Quality Control

Every batch of Glucose, L-, [1-14C] is manufactured and analyzed under strict quality control protocols to ensure the highest standards of radiochemical purity and chemical identity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed data on specific activity, radiochemical purity (typically >97% by HPLC), and chemical purity.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the container in a cool, dry, and well-ventilated area, away from incompatible materials. Follow all applicable radiation safety regulations for the storage of radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97% radiochemical purity
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (for solution forms)	Ethanol:Water (Contact for ratio)
Radioactivity Concentration	1 mCi/mL (Contact for specific batch data)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.