Description

Apararenone is a potent, non-steroidal mineralocorticoid receptor antagonist (MRA) with a high degree of selectivity. This compound is of significant interest in pharmaceutical research and development for its potential therapeutic applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel treatments for cardiovascular and renal diseases.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs).
• Cardiovascular Research: Used in preclinical studies to investigate new therapies for conditions like hypertension and heart failure.
• Renal Disease Research: Applied in research models to study its effects on diabetic nephropathy, chronic kidney disease, and fibrosis.
• Mechanistic Studies: Employed as a selective tool compound to study mineralocorticoid receptor pathways and their physiological roles.
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Formulation Development: Supports early-stage formulation work for potential drug products containing this class of molecule.

Basic Information

Product Name	Apararenone
CAS No.	945966-46-1
Molecular Formula	C₂₄H₂₅N₃O₄
Molecular Weight	419.48 g/mol
Synonyms	MT-3995; BAY 94-8862; 4-[5S,7R,8S,9S,10R,13S,14S,17R)-17-Hydroxy-3-oxo-2,3':6,7-disecoestra-1,3,5(10)-triene-6,17-diyl]benzonitrile; 4-[(5S,7R,8S,9S,10R,13S,14S,17R)-17-Hydroxy-3-oxo-2,3-secoestra-1,3,5(10)-triene-2,6-dione-17-yl]benzonitrile; Non-steroidal Mineralocorticoid Receptor Antagonist MT3995
EINECS	Contact for details

Quality Control

Our Apararenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.