Description

(R)-Bethanechol is the pharmacologically active enantiomer of the cholinergic agonist bethanechol. This high-purity chiral building block is critical for research and development in medicinal chemistry, particularly for studying stereospecific receptor interactions. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on developing or analyzing cholinergic agents. The compound's defined stereochemistry enables precise biological evaluation and synthesis of targeted therapeutics.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the identification, assay, and impurity profiling of bethanechol drug substances and products in compliance with pharmacopeial methods (e.g., USP, EP).
• Medicinal Chemistry Research: Used as a key chiral intermediate or pharmacological tool in the discovery and development of new muscarinic acetylcholine receptor agonists.
• Metabolic and Pharmacokinetic Studies: Employed in in vitro and in vivo studies to investigate the stereoselective metabolism, distribution, and action of cholinergic compounds.
• Analytical Method Development: Essential for developing and validating enantioselective analytical methods, such as chiral HPLC or CE, for quality control in pharmaceutical manufacturing.
• Biochemical Assays: Acts as a selective agonist in functional assays to characterize receptor subtypes and screen for potential modulators in drug discovery pipelines.

Basic Information

Product Name	(R)-Bethanechol
CAS No.	944538-49-2
Molecular Formula	C7H17N2O2+ Cl-
Molecular Weight	196.68 (free base)
Synonyms	(R)-2-[(Aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium Chloride; (R)-Bethanechol Chloride; (R)-Urecholine; (R)-Carbamylmethylcholine; (R)-Carbachol derivative; (R)-Muscarinic Agonist; (R)-MCN-A-343 analog; (R)-Enantiomer of Bethanechol
EINECS	Contact for details

Quality Control

Our (R)-Bethanechol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and related substances are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.