Description

Neostigmine Bromide is a quaternary ammonium compound that functions as a reversible acetylcholinesterase inhibitor. This pharmacological action is critical for enhancing cholinergic transmission at neuromuscular junctions and autonomic ganglia. It is an essential active pharmaceutical ingredient (API) primarily utilized in the formulation of injectable solutions and ophthalmic preparations for the treatment of myasthenia gravis and reversal of non-depolarizing neuromuscular blockade.

Application

• Pharmaceutical API: Primary use as the active ingredient in parenteral formulations for the treatment of myasthenia gravis.
• Surgical Adjunct: Used to reverse the effects of non-depolarizing muscle relaxants (e.g., rocuronium, vecuronium) during anesthesia.
• Ophthalmic Solutions: Employed in the management of glaucoma and for inducing miosis during certain eye surgeries.
• Diagnostic Agent: Used in the Tensilon test for the diagnosis of myasthenia gravis.
• Postoperative Care: Administration to prevent or treat postoperative urinary retention and ileus.
• Research & Development: Serves as a standard acetylcholinesterase inhibitor in pharmacological and neurological research studies.

Basic Information

Product Name	Neostigmine Bromide
CAS No.	114-80-7
Molecular Formula	C12H19BrN2O2
Molecular Weight	303.20 g/mol
Synonyms	Neostigmine Bromide; (3-Dimethylcarbamoxyphenyl)trimethylammonium Bromide; Prostigmin Bromide; Synstigmin Bromide; Neoeserine Bromide; Ro 2-3198; EINECS 204-054-6; NSC 7765
EINECS No.	204-054-6

Quality Control

Our Neostigmine Bromide is manufactured under strict quality systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) detailing specifications and test results is provided with each batch to ensure traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be protected from humidity to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Microbial Limits	Meets Ph. Eur./USP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.