Description

Xanomeline is a potent and selective muscarinic acetylcholine receptor agonist, primarily targeting the M1 and M4 subtypes. This pharmacological profile makes it a compound of significant interest for advanced research into neurological pathways and cognitive function. It is a critical intermediate and reference standard for pharmaceutical R&D, particularly in the development of novel therapeutics for central nervous system disorders. Researchers and manufacturers in the global pharmaceutical and biotechnology sectors rely on high-purity Xanomeline for preclinical studies and analytical method development.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and pharmacologically active compound for studying muscarinic receptor function and signal transduction.
• Neurological Disorder Studies: Used in preclinical research models targeting conditions such as Alzheimer's disease, schizophrenia, and other cognitive impairments.
• Drug Discovery Programs: Acts as a crucial intermediate or lead compound in the synthesis and screening of new chemical entities for CNS-targeted therapies.
• Analytical Method Development: Employed as a high-purity standard for calibrating equipment and validating analytical methods like HPLC and LC-MS in QC laboratories.
• Biochemical Assays: Utilized in in vitro assays to investigate receptor binding affinity, selectivity, and functional activity.
• Academic Research: Supports fundamental neuroscience and pharmacology studies in university and institutional research settings.

Basic Information

Product Name	Xanomeline
CAS No.	131986-45-3
Molecular Formula	C₁₇H₂₃N₃O₂S
Molecular Weight	333.45 g/mol
Synonyms	3-(3-Hexyloxy-1,2,5-thiadiazol-4-yl)-1,2,5,6-tetrahydro-1-methylpyridine; LY 246708; (3-Hexyloxy-1,2,5-thiadiazol-4-yl)-1-methyl-1,2,5,6-tetrahydropyridine; 1-Methyl-1,2,5,6-tetrahydro-3-(3-hexyloxy-1,2,5-thiadiazol-4-yl)pyridine; Xanomeline Tartrate (salt form precursor)
EINECS	Contact for details

Quality Control

Our Xanomeline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via advanced chromatographic techniques. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.