Description

Atropine Sulfate Monohydrate is a high-purity, crystalline salt of the tropane alkaloid atropine. This compound is a critical pharmaceutical active ingredient and research chemical, valued for its potent anticholinergic and antimuscarinic properties. It is essential for manufacturers in the pharmaceutical, biotechnology, and life science research sectors requiring a reliable and consistent supply of this key intermediate and active pharmaceutical ingredient (API).

Application

• Pharmaceutical Manufacturing: Primary use as an Active Pharmaceutical Ingredient (API) in injectable formulations, ophthalmic solutions, and tablets.
• Medical Antidote: Key component in auto-injectors and emergency kits for the treatment of organophosphate and nerve agent poisoning.
• Ophthalmic Preparations: Used in eye drops and solutions for pupil dilation (mydriasis) and cycloplegia during eye examinations and surgeries.
• Pre-Anesthetic Medication: Employed to reduce salivary and bronchial secretions before surgery.
• Bradycardia Treatment: Used in clinical settings to increase heart rate in specific cardiac conditions.
• Biochemical Research: Serves as a standard and tool compound in pharmacological studies targeting muscarinic acetylcholine receptors.
• Veterinary Medicine: Utilized in formulations for similar indications in animals, including as a pre-anesthetic.

Basic Information

Product Name	Atropine Sulfate Monohydrate
CAS No.	5908-99-6
Molecular Formula	C34H48N2O10S · H2O
Molecular Weight	694.83 g/mol
Synonyms	Atropine Sulphate Monohydrate; (RS)-Atropine Sulfate Monohydrate; dl-Hyoscyamine Sulfate Monohydrate; 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 3-hydroxy-2-phenylpropanoate sulfate monohydrate; Tropine tropate sulfate monohydrate; Atropinol; Atropin sulfat monohydrat
EINECS	227-575-4

Quality Control

Our Atropine Sulfate Monohydrate is produced and tested under a strict quality management system. It meets exacting standards for pharmaceutical intermediates and can be supplied to align with various pharmacopoeial monographs, including USP and EP. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles to ensure traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (Titration)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
pH (5% solution)	4.5 - 6.0
Specific Rotation	-0.3° to +0.3°
Water (Karl Fischer)	2.0% - 3.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.