Description

Tacrine Hydrochloride is a high-purity pharmaceutical intermediate and research chemical. This compound is a potent acetylcholinesterase inhibitor, making it a critical building block in neurological and pharmacological research. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focused on central nervous system (CNS) therapeutics.

Application

• Key intermediate in the synthesis of advanced pharmaceutical compounds targeting neurological pathways.
• Critical reference standard and active material in acetylcholinesterase inhibition studies for Alzheimer's disease research.
• Building block for the development and validation of novel cognitive enhancers and nootropic agents.
• Used in biochemical assays to study cholinergic system function and receptor interactions.
• Starting material for the preparation of labeled analogs (e.g., isotopically labeled) for pharmacokinetic and metabolic studies.
• Essential reagent in academic and industrial laboratories investigating treatments for myasthenia gravis and other cholinergic disorders.

Basic Information

Product Name	Tacrine Hydrochloride
CAS No.	1684-40-8
Molecular Formula	C13H15ClN2
Molecular Weight	234.72 g/mol
Synonyms	1,2,3,4-Tetrahydro-9-acridinamine monohydrochloride; 9-Amino-1,2,3,4-tetrahydroacridine hydrochloride; THA hydrochloride; Cognex (brand name reference); Tacrine HCl; Tetrahydroaminoacridine hydrochloride; 9-Amino-1,2,3,4-tetrahydroacridinium chloride
EINECS	Contact for details

Quality Control

Our Tacrine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of residual solvents and related substances. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and pharmaceutical-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.