Description

Neostigmine Methyl Sulfate is a quaternary ammonium compound that acts as a reversible acetylcholinesterase inhibitor. This pharmacological action is critical for enhancing neuromuscular transmission and increasing muscle tone. It is an essential active pharmaceutical ingredient (API) primarily required by the pharmaceutical industry for the formulation of injectable solutions used in anesthesia and to treat conditions like myasthenia gravis and postoperative urinary retention.

Application

• Pharmaceutical API: Primary use as the active ingredient in injectable formulations for the reversal of non-depolarizing neuromuscular blocking agents.
• Myasthenia Gravis Treatment: Used in diagnostic testing and management of this autoimmune neuromuscular disorder.
• Postoperative Care: Administration to stimulate bladder and gastrointestinal muscle activity to prevent urinary retention and paralytic ileus after surgery.
• Anesthesiology: Critical agent in surgical settings to rapidly restore muscle function at the conclusion of procedures.
• Research & Development: Used in biochemical and pharmacological studies related to cholinergic systems and neuromuscular junction physiology.
• Veterinary Medicine: Employed in veterinary practice for similar therapeutic purposes in animals.

Basic Information

Product Name	Neostigmine Methyl Sulfate
CAS No.	51-60-5
Molecular Formula	C13H22N2O6S
Molecular Weight	334.39 g/mol
Synonyms	Neostigmine Metilsulfate; (3-[(Dimethylcarbamoyl)oxy]-N,N,N-trimethylbenzenaminium Methyl Sulfate); Prostigmin Methylsulfate; Neostigmine Metilsulfate; Synstigmin; Neostigminum; EINECS 200-100-9; Benzenaminium, 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-, methyl sulfate (1:1)
EINECS	200-100-9

Quality Control

Our Neostigmine Methyl Sulfate is manufactured under strict quality systems suitable for pharmaceutical applications. It is typically produced to meet or exceed relevant pharmacopoeial standards such as USP (United States Pharmacopeia) and EP (European Pharmacopoeia). Every batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting all test results is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.