Description

Peficitinib is a potent and selective Janus kinase (JAK) inhibitor, a key compound in the development of advanced immunomodulatory therapies. Its primary value lies in its targeted mechanism of action, which is critical for research into the treatment of autoimmune and inflammatory diseases. This high-purity active pharmaceutical ingredient (API) is essential for pharmaceutical R&D teams, formulation scientists, and manufacturers engaged in developing novel therapeutics for conditions such as rheumatoid arthritis and other immune-mediated disorders.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key therapeutic component in finished drug products.
• Research & Development: Critical for preclinical and clinical studies investigating JAK inhibition pathways.
• Formulation Development: Used in the development of various dosage forms, including tablets and capsules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in laboratories.
• Mechanistic Studies: Employed in biochemical and cellular assays to study immune cell signaling and cytokine function.
• Process Chemistry: Used as an intermediate or final product in the scale-up and optimization of synthetic routes.

Basic Information

Item	Details
Product Name	Peficitinib
CAS No.	944118-01-8
Molecular Formula	C₂₅H₂₈N₆O₂
Molecular Weight	444.53 g/mol
Synonyms	ASP015K; JNJ-54781532; 3-[(3R,4R)-4-Methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]-3-oxopropanenitrile; Smyraf; (3R,4R)-4-Methyl-1-[2-cyanoacetyl]-N-methyl-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-3-carboxamide
EINECS	Contact for details

Quality Control

Our Peficitinib is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical development. Each batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.