Description

Ascomycin is a potent macrolide immunosuppressant and a structural analog of tacrolimus (FK506). This compound is of significant interest in biomedical research due to its specific mechanism of action, which involves binding to FK506-binding proteins (FKBPs) and inhibiting calcineurin. It is primarily utilized by pharmaceutical R&D laboratories and academic institutions for studying T-cell activation pathways, developing novel immunosuppressive therapies, and as a critical reference standard in analytical chemistry.

Application

• Immunology Research: A key tool for investigating T-cell signaling, cytokine production, and the calcineurin/NFAT pathway.
• Drug Discovery: Serves as a lead compound or reference molecule for developing new immunosuppressive and anti-inflammatory agents.
• Biochemical Assays: Used as a specific inhibitor in enzymatic and cellular assays to study FKBP12 and related protein functions.
• Reference Standard: Essential high-purity material for quality control and method validation in pharmaceutical analysis (HPLC, LC-MS).
• Dermatology Research: Studied for its potential topical application in treating inflammatory skin conditions.
• Neuroprotection Studies: Investigated for its role in neuronal protection and potential applications in neurodegenerative disease models.

Basic Information

Product Name	Ascomycin
CAS No.	104987-12-4
Molecular Formula	C43H69NO12
Molecular Weight	792.00 g/mol
Synonyms	Immunomycin; FR-900520; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxazacyclotricosine-1,7,20,21(4H,23H)-tetrone; FK-520; L-683,590
EINECS	Contact for details

Quality Control

Our Ascomycin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.