Description

Ascomycin is a potent macrolide immunosuppressant and antibiotic compound with significant research and pharmaceutical value. Its primary mechanism involves the selective inhibition of T-cell activation, making it a critical tool for studying immune pathways and a key precursor in drug development. This high-purity compound is essential for researchers and manufacturers in the fields of immunology, transplant medicine, and dermatology, particularly for investigating novel therapeutic agents.

Application

• Immunosuppressant Research: A vital reference standard and active pharmaceutical ingredient (API) in preclinical studies for autoimmune diseases and organ transplant rejection.
• Drug Discovery & Development: Serves as a lead compound and chemical intermediate for synthesizing novel analogs with improved efficacy and safety profiles.
• Biochemical Tool Compound: Used in molecular biology and cell-based assays to study calcineurin inhibition and T-cell signaling pathways.
• Dermatological Research: Investigated for its potential in treating inflammatory skin conditions like atopic dermatitis and psoriasis.
• Antifungal Agent Studies: Explored for its inherent antibiotic activity against certain fungi, supporting antimicrobial research programs.
• GMP Manufacturing: Sourced as a high-quality starting material for the production of advanced pharmaceutical intermediates under controlled conditions.

Basic Information

Product Name	Ascomycin
CAS No.	11011-38-4
Molecular Formula	C43H69NO12
Molecular Weight	792.00 g/mol
Synonyms	FR-900520; Immunomycin; (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,8,16,18,19-Pentahydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylvinyl]-14,15-dimethoxy-4,10,12,16-tetramethyl-9-oxo-1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,21,22,23,24,25,26,26a-tricosahydro-18H-1,17:19,20-dietheno-8,22:23,26-diepoxy-4H-pyrido[2,1-c][1,4]oxazacyclohentriacontine-7-carboxamide; FK-520; L-683,590
EINECS	Contact for details

Quality Control

Our Ascomycin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, spectroscopic identification (IR, NMR), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support development and commercial projects requiring material traceable to GMP, ICH guidelines, and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.