Description

Rapamycin is a potent macrocyclic lactone and a key mTOR (mechanistic target of rapamycin) inhibitor with significant biological activity. This compound is crucial for research and development in life sciences due to its role in modulating cell growth, proliferation, and autophagy. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies for applications in immunology, oncology, and aging studies.

Application

• Immunosuppressive Research: A critical tool for studying T-cell activation and transplant rejection mechanisms.
• Oncology Research: Investigated for its anti-proliferative effects and potential in cancer therapy development.
• Aging and Longevity Studies: Used in research exploring mTOR pathway inhibition to extend lifespan and healthspan.
• Cardiovascular Research: Employed in studies related to restenosis and cardiac cell growth regulation.
• Neurobiology: Applied in research on neurodegenerative diseases and neuronal cell survival.
• Biochemical Pathway Analysis: Serves as a selective probe to dissect the PI3K/Akt/mTOR signaling pathway.
• Drug Discovery: Acts as a lead compound or reference standard in the development of novel mTOR inhibitors.
• Cell Culture: Used to synchronize cells or study autophagy in various in vitro models.

Basic Information

Product Name	Rapamycin
CAS No.	53123-88-9
Molecular Formula	C51H79NO13
Molecular Weight	914.17 g/mol
Synonyms	Sirolimus; AY 22989; NSC-226080; Rapamune; Antibiotic AY 22989; (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
EINECS	Contact for details

Quality Control

Our Rapamycin is produced under strict quality management systems to ensure high purity and batch-to-batch consistency. Each lot undergoes comprehensive analytical testing, including HPLC for assay and related substances, to meet the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere to minimize oxidation. For long-term storage, keep desiccated to maintain stability. Allow the product to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.