Description

8-(n-Methylalanine)Cyclosporin A is a chemically modified derivative of the potent immunosuppressive cyclic peptide, Cyclosporin A. This specific analog is of significant interest in pharmaceutical research and development for its potential to modulate the biological activity and pharmacokinetic profile of the parent compound. It serves as a critical intermediate and reference standard for scientists in the fields of immunology and medicinal chemistry. Target industries include pharmaceutical R&D, biotechnology, and fine chemical synthesis for the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the research and synthesis of novel immunosuppressive agents and prodrugs.
• Medicinal Chemistry Research: Used as a reference compound for structure-activity relationship (SAR) studies to understand the impact of amino acid substitution on Cyclosporin A's bioactivity.
• Biochemical Tool: Employed in biochemical assays to investigate the mechanisms of immunophilin binding and calcineurin inhibition.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in HPLC and LC-MS analysis of cyclosporine derivatives.
• Academic & Institutional Research: Utilized in university and research institute laboratories for fundamental studies in immunology and drug discovery.

Basic Information

Product Name	8-(n-Methylalanine)Cyclosporin A
CAS No.	108466-41-7
Molecular Formula	C63H113N11O12
Molecular Weight	1208.64 g/mol
Synonyms	[MeAla]8-Cyclosporin A; Cyclosporin A, 8-(N-methylalanine)-; 8-(N-Methyl-L-alanine)cyclosporin A; (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(E,1R,2R)-1-hydroxy-2-methyl-4-hexen-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(1-methylethyl)-3,21-di(1-methylethyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone; 8-(N-Methylalanine)-Cyclosporin; 8-(N-Me-Ala)-CyA
EINECS	Contact for details

Quality Control

Our 8-(n-Methylalanine)Cyclosporin A is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.