Description

Cyclosporin A, 9-(4-Hydroxy-n-Methyl-L-Leucine)- CAS NO 107335-26-2 is a specific, modified analog of the well-known immunosuppressive cyclic peptide Cyclosporin A. This compound is of significant interest for advanced pharmaceutical research and development, particularly in the study of structure-activity relationships and the development of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on immunology and drug discovery.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis and study of novel immunosuppressive agents.
• Immunology Studies: Used in biochemical and cellular assays to investigate the mechanisms of T-cell activation and cytokine modulation.
• Structure-Activity Relationship (SAR) Analysis: Critical for medicinal chemistry programs aiming to optimize the potency, selectivity, and pharmacokinetic profile of cyclosporine derivatives.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical manufacturing.
• Fine Chemical Synthesis: Employed as a specialized building block for the custom synthesis of complex peptide-based molecules.

Basic Information

Product Name	Cyclosporin A, 9-(4-Hydroxy-n-Methyl-L-Leucine)- CAS NO 107335-26-2
CAS No.	107335-26-2
Molecular Formula	C62H111N11O13
Molecular Weight	1218.61 g/mol
Synonyms	Cyclosporin A, 9-(4-Hydroxy-n-Methyl-L-Leucine)-; [4-Hydroxy-N-methyl-L-leucine]9-Cyclosporin A; Cyclosporin A, 9-(4-Hydroxy-N-methyl-L-leucine) derivative; 9-(4-Hydroxy-N-methyl-L-leucine)cyclosporin A; Cyclosporine A analog; CsA derivative; Immunosuppressant analog; Ciclosporin A derivative
EINECS	Contact for details

Quality Control

Our Cyclosporin A, 9-(4-Hydroxy-n-Methyl-L-Leucine)- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications and test results are provided to ensure traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept tightly sealed in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.