Description

6-[(3R,4R)-3-(Acetyloxy)-N,4-Dimethyl-6-Oxo-L-Norleucine] Cyclosporin A is a chemically modified derivative of the potent immunosuppressive cyclic peptide, Cyclosporin A. This derivative is of significant interest for pharmaceutical research and development, particularly in the study of structure-activity relationships and the development of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on immunology and advanced drug discovery.

Application

• Pharmaceutical Research & Development: A key intermediate or reference standard in the synthesis and study of novel immunosuppressive agents.
• Structure-Activity Relationship (SAR) Studies: Used to investigate how specific chemical modifications affect the biological activity and pharmacokinetics of Cyclosporin analogs.
• Biochemical Research: Employed as a tool compound in immunology research to probe cellular pathways and receptor interactions.
• Fine Chemical Synthesis: Serves as a high-value building block for the custom synthesis of specialized peptides and complex organic molecules for clinical trials.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control of related Cyclosporin-based products.

Basic Information

Product Name	6-[(3R,4R)-3-(Acetyloxy)-N,4-Dimethyl-6-Oxo-L-Norleucine] Cyclosporin A
CAS No.	121584-52-9
Molecular Formula	C65H113N11O14
Molecular Weight	1264.66 g/mol
Synonyms	Cyclosporin A, 6-[(3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine]-; [6-[(3R,4R)-3-(Acetyloxy)-N,4-Dimethyl-6-Oxo-L-Norleucine]]-Cyclosporin A; Cyclosporin A Derivative; Modified Cyclosporin A; CsA Derivative; Immunosuppressant Derivative; (3R,4R)-3-(Acetyloxy)-N,4-dimethyl-6-oxo-L-norleucine Cyclosporin A
EINECS	Contact for details

Quality Control

Our production of this high-purity research chemical adheres to stringent quality protocols. Every batch is characterized and tested to ensure identity, purity, and consistency, supporting reliable and reproducible research outcomes. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and identification is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.