Description

Cyclosporin A, 4-(2-Butenyl)-4,4,n-Trimethylthreonine(1)- CAS NO 114865-22-4 is a chemically modified derivative of the potent immunosuppressive agent Cyclosporin A. This compound is of significant interest for pharmaceutical research and development, particularly in the study of structure-activity relationships to enhance therapeutic efficacy and reduce side effects. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in advanced immunology studies and novel drug discovery programs.

Application

• Immunosuppressive Research: A key reference standard for investigating the mechanisms of action and metabolic pathways of cyclosporine analogs.
• Structure-Activity Relationship (SAR) Studies: Used to elucidate how specific chemical modifications to the Cyclosporin A core structure influence biological activity and binding affinity.
• Pharmaceutical Intermediate: Serves as a critical synthetic intermediate in the development of next-generation immunosuppressive therapies.
• Biochemical Assay Development: Employed as a calibrant or control in the development of analytical methods (e.g., HPLC, LC-MS) for quantifying cyclosporine derivatives.
• Preclinical Drug Evaluation: Used in in vitro and in vivo models to assess the pharmacokinetic and pharmacodynamic profiles of modified cyclosporins.

Basic Information

Product Name	Cyclosporin A, 4-(2-Butenyl)-4,4,n-Trimethylthreonine(1)-
CAS No.	114865-22-4
Molecular Formula	C65H113N11O12
Molecular Weight	1240.66 g/mol
Synonyms	[4-(2-Butenyl)-4,N-dimethyl-L-threonine]cyclosporin A; [4-(2-Butenyl)-4,N-dimethyl-L-threonine]-cyclosporin A; Cyclosporin A, [4-(2-Butenyl)-4,N-dimethyl-L-threonine]-; Cyclosporine A derivative (4-(2-Butenyl)-4,N-dimethyl-L-threonine); Modified Cyclosporin A; CsA derivative (Butenyl-dimethyl-threonine); Cyclosporin A analog (114865-22-4)
EINECS	Contact for details

Quality Control

Our Cyclosporin A derivative is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and structural confirmation, to ensure identity, potency, and consistency. Certificates of Analysis (COA) detailing specific results for purity, related substances, and other critical parameters are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.