Description

Cyclosporin A, 1-[(2S)-2-Aminobutanoic Acid]- CAS NO 108027-46-9 is a chemically modified derivative of the potent immunosuppressive agent Cyclosporin A. This compound is engineered to enhance specific pharmacological properties, making it a critical intermediate for advanced pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the fields of immunology, oncology, and drug discovery who require high-purity, well-characterized chemical entities for novel therapeutic applications.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel immunosuppressive drugs and prodrugs.
• Biochemical Research: Used as a reference standard and active compound in studies investigating T-cell activation, cytokine modulation, and autoimmune disease mechanisms.
• Drug Discovery & Development: Employed in high-throughput screening and structure-activity relationship (SAR) studies to develop next-generation immunomodulators.
• Academic Research: A vital tool for universities and research institutes exploring cellular signaling pathways and transplant medicine.
• API Synthesis: Acts as a precursor in the controlled synthesis of Active Pharmaceutical Ingredients (APIs) with targeted delivery profiles.

Basic Information

Product Name	Cyclosporin A, 1-[(2S)-2-Aminobutanoic Acid]-
CAS No.	108027-46-9
Molecular Formula	C63H113N11O13
Molecular Weight	1208.64 g/mol
Synonyms	1-[(2S)-2-Aminobutanoic Acid] Cyclosporin A; Cyclosporin A Derivative; [Aib2, Abu1]-Cyclosporin A; Cyclosporin A, 1-(L-2-Aminobutyric Acid); CsA-Abu; Cyclosporine A Analog; Immunosuppressant Derivative; Ciclosporin A Modified
EINECS	Contact for details

Quality Control

Our Cyclosporin A, 1-[(2S)-2-Aminobutanoic Acid]- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and related substances. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. Due to its hygroscopic (moisture-sensitive) nature, the container should be sealed under an inert atmosphere after opening and allowed to equilibrate to room temperature before use to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.