Description

Pimecrolimus is a selective calcineurin inhibitor belonging to the class of ascomycin macrolactam derivatives. This compound is of significant commercial and therapeutic importance due to its potent anti-inflammatory and immunomodulating properties. It is primarily required by the pharmaceutical industry for the formulation of topical treatments for inflammatory skin conditions.

Application

• Active Pharmaceutical Ingredient (API) in topical creams and ointments for the treatment of atopic dermatitis (eczema).
• Key intermediate in advanced pharmaceutical research and development of novel immunomodulatory therapies.
• Reference standard for quality control and analytical testing in pharmaceutical manufacturing and regulatory laboratories.
• Research chemical for in-vitro and in-vivo studies investigating T-cell activation and cytokine production pathways.
• Formulation component for veterinary dermatology products targeting inflammatory skin disorders in animals.

Basic Information

Product Name	Pimecrolimus
CAS No.	102203-23-6
Molecular Formula	C43H68ClNO11
Molecular Weight	810.46 g/mol
Synonyms	SDZ ASM 981; ASM 981; Elidel (Trade Name); (1R,9S,12S,13R,14S,17R,18E,21S,23S,24R,25S,27R)-12-[(1E)-1-[(1R,3R,4S)-4-chloro-3-methoxycyclohexyl]prop-1-en-2-yl]-17-ethyl-1,14-dihydroxy-23,25-dimethoxy-13,19,21,27-tetramethyl-11,28-dioxa-4-azatricyclo[22.3.1.04,9]octacos-18-ene-2,3,10,16-tetrone; 33-Epi-chloro-33-desoxyascomycin
EINECS	Contact for details

Quality Control

Our Pimecrolimus is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with relevant guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.