Description

4-Hydroxy-2-(Trifluoromethyl)Phenylboronic Acid is a specialized organoboron compound that serves as a critical building block in modern synthetic chemistry. Its value lies in the unique combination of a boronic acid functional group and a trifluoromethyl-substituted phenol structure, enabling precise cross-coupling reactions and the introduction of desirable fluorinated motifs. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly where enhanced metabolic stability and lipophilicity are required.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing complex biaryl structures found in drug candidates.
• Agrochemical Synthesis: Used to construct fluorinated aromatic cores in advanced herbicides, fungicides, and insecticides to improve efficacy and environmental profile.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where the CF3 group tunes electronic properties.
• Ligand and Catalyst Design: Serves as a starting material for creating novel bidentate ligands and organocatalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the synthesis of fluorinated molecular probes and tags for studying biological processes and protein interactions.
• Fluorine Chemistry: Acts as a versatile scaffold for introducing the trifluoromethyl group into more complex molecular architectures.

Basic Information

Product Name	4-Hydroxy-2-(Trifluoromethyl)Phenylboronic Acid
CAS No.	943918-05-6
Molecular Formula	C7H6BF3O3
Molecular Weight	205.93 g/mol
Synonyms	2-(Trifluoromethyl)-4-hydroxybenzeneboronic Acid; (4-Hydroxy-2-(trifluoromethyl)phenyl)boronic Acid; 4-Hydroxy-2-trifluoromethylbenzeneboronic Acid; 4-Hydroxy-α,α,α-trifluoro-o-tolylboronic Acid; B-[4-Hydroxy-2-(trifluoromethyl)phenyl]boronic Acid; 2-Trifluoromethyl-4-hydroxy-phenylboronic acid
EINECS	Contact for details

Quality Control

Every batch of 4-Hydroxy-2-(Trifluoromethyl)Phenylboronic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high-purity standards required for advanced synthetic applications. Our products are supported by comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles. We adhere to relevant industry guidelines and can supply material tailored to specific research or cGMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.