Description

Amiselimod (MT-1303) Free Base is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, representing a significant class of immunomodulatory agents. Its primary value lies in its potential to suppress lymphocyte egress from lymphoid organs, making it a compound of high interest for therapeutic development. This active pharmaceutical ingredient (API) is essential for researchers and pharmaceutical manufacturers focused on advancing treatments for autoimmune and inflammatory diseases, such as multiple sclerosis and ulcerative colitis. The compound is supplied as a high-purity free base to facilitate formulation studies and clinical research.

Application

• Pharmaceutical Intermediate: Serves as the key active pharmaceutical ingredient (API) in the development of novel immunomodulatory drugs.
• Autoimmune Disease Research: Critical for preclinical and clinical research targeting conditions like multiple sclerosis, psoriasis, and inflammatory bowel disease (IBD).
• Mechanistic Studies: Used in biochemical and pharmacological research to study S1P1 receptor signaling pathways and lymphocyte trafficking.
• Formulation Development: Employed in the development of various dosage forms, including oral tablets and capsules, due to its free base properties.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in drug manufacturing.

Basic Information

Product Name	Amiselimod (MT-1303) Free Base
CAS No.	942399-20-4
Molecular Formula	C23H30FN3O2
Molecular Weight	399.51 g/mol
Synonyms	MT-1303; MT1303; Amiselimod; (R)-2-Amino-2-[4-(5-{4-[(1R)-1-[(2-chloro-4-fluorophenyl)methyl]-2-hydroxyethyl]-1,3-oxazol-2-yl}butyl)phenyl]propan-1-ol; (R)-2-Amino-2-[4-[5-[4-[(1R)-1-[(2-chloro-4-fluorophenyl)methyl]-2-hydroxyethyl]-1,3-oxazol-2-yl]butyl]phenyl]propan-1-ol; BAF-312 (related to the phosphate salt); Etrasimod (is a different S1P modulator, but often searched alongside).
EINECS	Contact for details

Quality Control

Our Amiselimod (MT-1303) Free Base is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and identification by spectroscopic methods (IR, NMR, MS), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C (59-77°F), in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.