Description

S-Ruxolitinib (INCB018424) is a potent and selective Janus kinase (JAK) inhibitor, specifically targeting JAK1 and JAK2. This high-purity chemical reference standard is critical for pharmaceutical research and development, enabling the study of JAK-STAT signaling pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery, preclinical studies, and analytical method development.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for quality control and analytical method validation in drug manufacturing.
• Biochemical Research: A key tool for in vitro and in vivo studies investigating JAK-STAT pathway inhibition, cytokine signaling, and immunology.
• Drug Discovery & Development: Serves as a lead compound or intermediate in the synthesis and development of novel JAK inhibitor therapeutics.
• Preclinical Studies: Employed in animal models to evaluate the efficacy and pharmacokinetics of JAK inhibition for various conditions.
• Mechanism of Action Studies: Essential for elucidating the precise biological targets and downstream effects of JAK inhibition.

Basic Information

Product Name	S-Ruxolitinib (INCB018424)
CAS No.	941685-37-6
Molecular Formula	C17H18N6
Molecular Weight	306.36 g/mol
Synonyms	(3R)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile; (R)-Ruxolitinib; Ruxolitinib S-enantiomer; INCB-018424; INCB 018424; INCBO18424; Jakafi (brand name reference); JAK1/JAK2 Inhibitor
EINECS	Contact for details

Quality Control

Our S-Ruxolitinib is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.