Description

2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is a high-value, multi-functional boronic ester derivative of aniline, serving as a critical synthetic intermediate. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental for constructing complex molecular architectures in advanced research and development. This compound is essential for pharmaceutical chemists, agrochemical researchers, and material scientists engaged in the discovery and synthesis of novel active ingredients, functional polymers, and electronic materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides that incorporate fluorinated aniline motifs for enhanced efficacy and environmental profile.
• Material Science Research: Serves as a precursor for creating advanced organic electronic materials, including organic light-emitting diodes (OLEDs), semiconductors, and liquid crystals.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes, tags, and inhibitors for studying biological processes and protein function.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to introduce the 2,6-difluoro-4-aminophenyl moiety into complex molecules.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline
CAS No.	939968-08-8
Molecular Formula	C12H16BF2NO2
Molecular Weight	255.07 g/mol
Synonyms	4-Amino-3,5-difluorophenylboronic acid pinacol ester; 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-difluoroaniline; 3,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; 2,6-Difluoro-4-aminophenylboronic acid pinacol ester; (4-Amino-3,5-difluorophenyl)boronic acid pinacol ester; AN-329/25039745; 939968-08-8
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, assay, and impurity profiles. Our quality commitment supports applications in GMP and ISO-regulated environments, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.