Description

3-(2,6-Difluorophenyl)Prop-2-Ynoic Acid is a specialized fluorinated organic building block characterized by its propiolic acid core and difluorophenyl substituent. This compound matters as a high-value synthetic intermediate, offering a unique combination of acidity and fluorine chemistry for constructing complex molecular architectures. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers and advanced organic electronic materials.
• Chemical Synthesis: Acts as a versatile precursor for Sonogashira coupling, click chemistry, and other metal-catalyzed reactions to create complex alkynes and conjugated systems.
• Ligand & Catalyst Development: Utilized in the design of novel ligands for catalysis and metal-organic frameworks (MOFs).
• Life Science Research: Employed as a biochemical probe or tool compound in medicinal chemistry programs for hit-to-lead optimization.

Basic Information

Product Name	3-(2,6-Difluorophenyl)Prop-2-Ynoic Acid
CAS No.	935475-84-6
Molecular Formula	C9H4F2O2
Molecular Weight	182.13 g/mol
Synonyms	2,6-Difluorophenylpropiolic Acid; 3-(2,6-Difluorophenyl)propiolic Acid; 2,6-Difluorobenzeneacetic Acid, α-oxo-; Propiolic Acid, 3-(2,6-difluorophenyl)-; 935475-84-6; 3-(2,6-Difluorophenyl)-2-propynoic Acid
EINECS	Contact for details

Quality Control

Our 3-(2,6-Difluorophenyl)Prop-2-Ynoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.