Description

Nifeviroc CAS NO 934740-33-7 is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) compound of significant interest in pharmaceutical research and development. This compound serves as a critical intermediate or active pharmaceutical ingredient (API) in the synthesis of novel antiviral therapeutics. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in virology and drug discovery programs targeting HIV and related retroviruses.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced NNRTI drug candidates for HIV treatment.
• Antiviral Research: Reference standard and active compound in biochemical assays and virology studies to evaluate efficacy against HIV-1 and HIV-2 strains.
• Mechanistic Studies: Used in structural biology and computational modeling to understand drug-receptor interactions and resistance mechanisms.
• Preclinical Development: Serves as a critical material for pharmacokinetic, pharmacodynamic, and toxicology studies during early drug development phases.
• Process Chemistry: Employed in the development and optimization of scalable synthetic routes for antiviral APIs under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	Nifeviroc
CAS No.	934740-33-7
Molecular Formula	C20H15F3N4O3S
Molecular Weight	448.42 g/mol
Synonyms	Nifeviroc; 4-[[4-[[4-(2-Cyanoethenyl)-2,6-dimethylphenyl]amino]-5-pyrimidinyl]oxy]-α,α-bis(trifluoromethyl)benzenemethanol; BMS-488043; BMS 488043; BMS488043; (αR)-4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-5-pyrimidinyl]oxy]-α,α-bis(trifluoromethyl)benzenemethanol
EINECS	Contact for details

Quality Control

Our Nifeviroc is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Quality is assured through comprehensive analytical testing including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each batch, confirming identity, purity, and impurity profiles. We adhere to relevant quality guidelines to support our global clientele in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.