Description

5-Fluoro-2-Trifluoromethyl-Phenylboronic Acid is a high-purity organoboron compound, specifically a boronic acid derivative, valued for its role as a versatile building block in modern synthetic chemistry. Its primary commercial significance lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for pharmaceutical and advanced material synthesis. This product is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce complex fluorinated aromatic motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl and fluoro substituents for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorinated phenyl group contributes to biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for constructing complex organic frameworks, liquid crystals, and polymers with tailored electronic and optical properties.
• Suzuki-Miyaura Cross-Coupling: The principal application is as a boron reagent for palladium-catalyzed cross-coupling with various organic halides, enabling efficient biaryl and heterobiaryl formation.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and diagnostic agents that leverage boronic acid chemistry for sensing or binding applications.

Basic Information

Product Name	5-Fluoro-2-Trifluoromethyl-Phenylboronic Acid
CAS No.	928053-97-8
Molecular Formula	C7H5BF4O2
Molecular Weight	207.92 g/mol
Synonyms	(5-Fluoro-2-(trifluoromethyl)phenyl)boronic acid; 2-Trifluoromethyl-5-fluorophenylboronic acid; 5-Fluoro-α,α,α-trifluoro-o-tolylboronic acid; B-[5-Fluoro-2-(trifluoromethyl)phenyl]boronic acid; 928053-97-8; 5-Fluoro-2-trifluoromethylbenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Trifluoromethyl-Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.