Description

2-Fluoro-5-(3-Trifluoromethylphenyl)Benzoic Acid is a high-value, multi-functional aromatic carboxylic acid derivative, distinguished by its unique trifluoromethyl and fluorine substituents. This compound is a critical advanced pharmaceutical intermediate (API intermediate) prized for its ability to impart metabolic stability and enhance lipophilicity in active molecules. It is primarily utilized by R&D and production teams in the pharmaceutical and agrochemical sectors for the synthesis of novel therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, antiviral, and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides, where the fluorine and trifluoromethyl groups contribute to biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the production of fluorine-containing liquid crystals for advanced display technologies.
• Organic Electronic Materials: Employed in the development of organic semiconductors and electron-transport materials due to its electron-withdrawing properties.
• Chemical Research & Development: A versatile reagent for Suzuki-Miyaura and other cross-coupling reactions to create complex biaryl structures in medicinal chemistry.
• Fluorinated Polymer Modifier: Acts as a monomer or additive to introduce specific properties like chemical resistance or altered surface energy into specialty polymers.

Basic Information

Product Name	2-Fluoro-5-(3-Trifluoromethylphenyl)Benzoic Acid
CAS No.	926235-51-0
Molecular Formula	C14H8F4O2
Molecular Weight	284.21 g/mol
Synonyms	2-Fluoro-5-[3-(trifluoromethyl)phenyl]benzoic Acid; 5'-Fluoro-3'-(trifluoromethyl)[1,1'-biphenyl]-2-carboxylic Acid; [1,1'-Biphenyl]-2-carboxylic acid, 5-fluoro-3'-(trifluoromethyl)-; 2-Fluoro-5-(3-trifluoromethyl-phenyl)-benzoic acid; 2-Fluoro-5-(α,α,α-trifluoro-m-tolyl)benzoic Acid
EINECS	Contact for details

Quality Control

Our production of 2-Fluoro-5-(3-Trifluoromethylphenyl)Benzoic Acid adheres to a stringent quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent batch-to-batch reliability. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.