Description

2-Ag-D8 is a deuterium-labeled analog of the cannabinoid receptor agonist 2-AG (2-arachidonoylglycerol), identified by CAS number 924894-97-3. This stable isotope-labeled compound is a critical tool for quantitative mass spectrometry, enabling precise pharmacokinetic and metabolic studies of the endocannabinoid system. It is primarily needed by pharmaceutical R&D laboratories, analytical chemists, and clinical researchers focused on neurobiology, pain management, and metabolic disorders.

Application

• Internal Standard for LC-MS/MS: Serves as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for accurate measurement of endogenous 2-AG levels in biological matrices.
• Metabolic Pathway Tracing: Used in deuterium tracing studies to investigate the biosynthesis, degradation, and enzymatic transformation pathways of endocannabinoids.
• Pharmacokinetic (PK) Studies: Essential for determining the absorption, distribution, metabolism, and excretion (ADME) profiles of cannabinoid-related drug candidates.
• Biomarker Research: Facilitates the development and validation of analytical methods for 2-AG as a potential biomarker in neurological and inflammatory diseases.
• Drug Discovery & Development: Supports high-throughput screening and target engagement studies for novel therapeutics targeting the CB1 and CB2 receptors.
• Quality Control & Method Validation: Employed in GLP/GMP-compliant laboratories to validate analytical methods for potency and impurity profiling of cannabinoid-based products.

Basic Information

Product Name	2-Ag-D8
CAS No.	924894-97-3
Molecular Formula	C₂₃H₃₀D₈O₄
Molecular Weight	~386.6 g/mol
Synonyms	2-Arachidonoylglycerol-d8; 2-AG-d8; 1,3-Dihydroxy-2-propanyl (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenoate-d8; Deuterated 2-AG; [²H₈]-2-AG; 2-AG Internal Standard; Endocannabinoid-d8; 2-AG (d8)
EINECS	Contact for details

Quality Control

Our 2-Ag-D8 is manufactured under strict quality protocols to ensure high chemical and isotopic purity suitable for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity by HPLC, isotopic enrichment by NMR or MS, and confirming structural identity. We adhere to relevant standards for high-purity reference materials to ensure reliable and reproducible results in your research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen), as the compound is easily oxidized. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 98% (Area %)
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms to structure
Solubility	Soluble in DMSO, ethanol, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.