Description

5-[3-(Trifluoromethoxy)Phenyl]Nicotinic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethoxy-substituted biphenyl structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate its distinct fluorinated aromatic moiety into new molecular entities.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the trifluoromethoxy group can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in catalytic systems or for metal-organic framework (MOF) construction.
• Material Science: Employed in the research of advanced polymers and organic electronic materials due to its aromatic and fluorinated components.
• Chemical Biology Probes: Utilized as a core structure for developing fluorescent tags or molecular probes for biochemical assays.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated nicotinic acid derivative.

Basic Information

Product Name	5-[3-(Trifluoromethoxy)Phenyl]Nicotinic Acid
CAS No.	924854-23-9
Molecular Formula	C13H8F3NO3
Molecular Weight	283.20 g/mol
Synonyms	5-[3-(Trifluoromethoxy)phenyl]pyridine-3-carboxylic acid; 3-Pyridinecarboxylic acid, 5-[3-(trifluoromethoxy)phenyl]-; Nicotinic acid, 5-[3-(trifluoromethoxy)phenyl]-; 5-(3-Trifluoromethoxyphenyl)nicotinic acid; 5-(3-(Trifluoromethoxy)phenyl)nicotinic acid
EINECS	Contact for details

Quality Control

Every batch of 5-[3-(Trifluoromethoxy)Phenyl]Nicotinic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes providing a detailed Certificate of Analysis (COA) with each shipment, which reports key parameters such as assay (HPLC), related substances, and residual solvents. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.