Description

4-(2,5-Difluorophenyl)Benzoic Acid is a high-purity fluorinated aromatic carboxylic acid building block. This compound is valued for its role as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its difluorophenyl moiety can significantly influence molecular properties. It is primarily sought by research and development teams, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Incorporated as a monomer or additive to impart specific thermal, chemical, or surface properties to high-performance polymers.
• Chemical Research & Development: A versatile reagent for coupling reactions (e.g., Suzuki, esterification) in academic and industrial R&D laboratories exploring new chemical entities.
• Coordination Chemistry: Acts as a ligand precursor for metal-organic frameworks (MOFs) and catalysts, leveraging the carboxylic acid functional group.

Basic Information

Product Name	4-(2,5-Difluorophenyl)Benzoic Acid
CAS No.	920294-24-2
Molecular Formula	C13H8F2O2
Molecular Weight	234.20 g/mol
Synonyms	[4-(2,5-Difluorophenyl)phenyl]formic acid; Benzoic acid, 4-(2,5-difluorophenyl)-; 2',5'-Difluoro[1,1'-biphenyl]-4-carboxylic acid; 4-(2,5-Difluorophenyl)benzenecarboxylic acid; 4-(2,5-Difluorophenyl)benzene-1-carboxylic acid; Biphenyl-4-carboxylic acid, 2',5'-difluoro-
EINECS	Contact for details

Quality Control

Our 4-(2,5-Difluorophenyl)Benzoic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request. We support compliance with cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.