Description

Ansofaxine (Hydrochloride) CAS NO 916918-84-8 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant interest in modern neuropsychiatric drug development. Its primary value lies in its role as a key synthetic precursor or active metabolite in the research and production of novel therapeutic agents targeting the central nervous system. This compound is essential for pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic institutions engaged in the synthesis of next-generation antidepressants and anxiolytics.

Application

• Pharmaceutical Intermediate: Critical building block in the multi-step synthesis of novel serotonin-norepinephrine reuptake inhibitors (SNRIs) and other psychotropic drugs.
• Active Pharmaceutical Ingredient (API) Research: Serves as a reference standard and active component in preclinical and clinical research for new chemical entities (NCEs).
• Metabolite Studies: Used in pharmacokinetic and pharmacodynamic studies to understand drug metabolism and activity profiles.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and pilot-scale manufacturing processes for drug candidates.
• Analytical Reference Standard: Provides a certified high-purity standard for method development, validation, and quality control (HPLC, LC-MS) in analytical laboratories.
• Academic & Institutional Research: Facilitates neuroscience and medicinal chemistry research in universities and government institutes.

Basic Information

Product Name	Ansofaxine (Hydrochloride)
CAS No.	916918-84-8
Molecular Formula	C17H19NO2 • HCl
Molecular Weight	305.80 g/mol
Synonyms	Ansofaxine HCl; (1R,2S)-2-[(Dimethylamino)methyl]-1-phenyl-3-(1,2,3,4-tetrahydro-2-naphthalenyloxy)propane hydrochloride; (1R,2S)-2-[(Dimethylamino)methyl]-1-phenyl-3-(1,2,3,4-tetrahydronaphthalen-2-yloxy)propane hydrochloride; LY-2216684 hydrochloride; Edivoxetine hydrochloride; (1R,2S)-N,N-Dimethyl-2-phenyl-3-[(1S,2R)-1,2,3,4-tetrahydronaphthalen-2-yloxy]propan-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our Ansofaxine (Hydrochloride) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical development. Specifications are aligned with ICH guidelines. A detailed Certificate of Analysis (COA) documenting results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.