Description

Desipramine Hydrochloride is a high-purity pharmaceutical active ingredient (API) and a key tricyclic antidepressant compound. It is essential for the development and manufacturing of critical neuropharmacological treatments. This compound is primarily required by pharmaceutical manufacturers, research institutions, and analytical laboratories for formulation, clinical studies, and quality control purposes.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of antidepressant medications.
• Reference Standard: Serves as a certified standard for analytical testing and quality assurance in pharmaceutical QC labs.
• Biochemical Research: Used in neuroscience and pharmacology research to study neurotransmitter reuptake inhibition mechanisms.
• Metabolite Studies: Critical for the analysis and synthesis of metabolic pathways related to imipramine and other tricyclic compounds.
• Impurity Profiling: Employed as a marker in the identification and quantification of related substances in drug substances and products.

Basic Information

Product Name	Desipramine Hydrochloride
CAS No.	58-28-6
Molecular Formula	C18H22N2·HCl
Molecular Weight	302.84 g/mol
Synonyms	Desipramine HCl; Norimipramine Hydrochloride; 10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepine Hydrochloride; Desmethylimipramine Hydrochloride; G-35020; JB-8181; NSC-114901; Pertofrane (brand name)
EINECS	200-378-7

Quality Control

Our Desipramine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmacopeial standards. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.