Description

Imipramine Hydrochloride is a tricyclic antidepressant (TCA) compound, widely recognized for its therapeutic efficacy. It is a critical active pharmaceutical ingredient (API) essential for the formulation of various antidepressant medications. This high-purity compound is primarily required by pharmaceutical manufacturers, research institutions, and analytical laboratories for drug development, production, and quality control.

Application

• Pharmaceutical API: Primary use as the active ingredient in the manufacture of antidepressant tablets, capsules, and other dosage forms.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality testing in QC/QA laboratories.
• Biochemical Research: Used in neuroscience and pharmacological studies to investigate the mechanisms of action of tricyclic antidepressants and neurotransmitter reuptake inhibition.
• Generic Drug Production: A key component in the synthesis of generic versions of established antidepressant medications.
• Clinical Research: Employed in the formulation of drugs for clinical trials studying depression and related mood disorders.

Basic Information

Product Name	Imipramine Hydrochloride
CAS No.	113-52-0
Molecular Formula	C19H24N2·HCl
Molecular Weight	316.87 g/mol
Synonyms	Imipramine HCl; 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride; N-(γ-Dimethylaminopropyl)iminodibenzyl hydrochloride; Tofranil (brand name); Imipraminium Chloride; Melipramine; IMI HCl
EINECS	204-030-5

Quality Control

Our Imipramine Hydrochloride is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each batch, confirming compliance with specifications for identity, purity, and impurities. We can supply material that conforms to various pharmacopeial standards, including USP and EP, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.