Description

Protriptyline Hydrochloride is a tricyclic antidepressant (TCA) compound, recognized for its potent norepinephrine reuptake inhibition. It is a critical active pharmaceutical ingredient (API) valued for its specific therapeutic profile and role in pharmaceutical research and development. This compound is essential for manufacturers in the pharmaceutical industry engaged in the formulation of antidepressant medications and for research institutions conducting neuropharmacological studies.

Application

• Active Pharmaceutical Ingredient (API): Primary use in the formulation of antidepressant and mood-stabilizing medications.
• Reference Standard: Serves as a high-purity standard in analytical laboratories for quality control and method validation.
• Pharmacological Research: A key compound in preclinical and clinical studies investigating the mechanisms of tricyclic antidepressants and neurotransmitter reuptake.
• Pharmaceutical Development: Used in the development of generic and novel drug formulations, dosage form studies, and stability testing.
• Biochemical Research: Employed in studies of adrenergic and serotonergic systems, receptor binding assays, and neurochemical pathway analysis.

Basic Information

Product Name	Protriptyline Hydrochloride
CAS No.	1225-55-4
Molecular Formula	C19H21N•HCl
Molecular Weight	299.84 g/mol
Synonyms	Protriptyline HCl; 5H-Dibenzo[a,d]cyclohepten-5-propanamine, N-methyl-, hydrochloride; Vivactil Hydrochloride; MK-240; N-Methyl-5H-dibenzo[a,d]cycloheptene-5-propylamine hydrochloride; Concordin; Triptil
EINECS	214-949-9

Quality Control

Our Protriptyline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide Certificates of Analysis (COA) detailing specifications for identity, purity, and impurities, referencing pharmacopeial methods where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a dry environment and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.