Description

Doxepin Hydrochloride is a tricyclic antidepressant compound widely recognized for its potent pharmacological activity. This active pharmaceutical ingredient (API) is critical for the formulation of medications used to treat major depressive disorder and anxiety-related conditions. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development and production of central nervous system (CNS) therapeutics.

Application

• Pharmaceutical API: Primary use as the active ingredient in antidepressant and anxiolytic drug formulations.
• Generic Drug Manufacturing: Sourcing for the production of generic versions of doxepin-based medications.
• Clinical Research: Utilization in preclinical and clinical studies for neurological and psychiatric disorders.
• Reference Standard: Serves as a high-purity analytical standard for quality control laboratories.
• Dosage Form Development: Used in R&D for creating tablets, capsules, and oral solutions.
• Biochemical Research: Investigation of histamine H1 and H2 receptor antagonism mechanisms.

Basic Information

Product Name	Doxepin Hydrochloride
CAS No.	1229-29-4
Molecular Formula	C19H22ClNO
Molecular Weight	315.84 g/mol
Synonyms	Doxepin HCl; NSC-108160; 3-Dibenz[b,e]oxepin-11(6H)ylidene-N,N-dimethyl-1-propanamine hydrochloride; Sinequan; Adapin; Deptran; Aponal; Quitaxon; (E)-Doxepin Hydrochloride; Doxepin Hydrochloride (USP)
EINECS	214-958-5

Quality Control

Our Doxepin Hydrochloride is manufactured under strict quality management systems. It undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including compliance with relevant pharmacopeial monographs. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to guarantee traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.