Description

Dothiepin is a tricyclic dibenzothiepin derivative with significant pharmacological activity. This compound is primarily valued as a key intermediate in the synthesis of advanced pharmaceutical agents, particularly in the development of central nervous system (CNS) therapeutics. It is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical suppliers focused on producing active pharmaceutical ingredients (APIs) and novel drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of tricyclic antidepressant drugs and related CNS-active compounds.
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new therapeutic agents targeting neurological pathways.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Active Pharmaceutical Ingredient (API) Synthesis: A key precursor in multi-step synthetic routes for the commercial production of specific pharmaceutical grade molecules.
• Biochemical Research: Utilized in pharmacological studies to investigate receptor binding and mechanism of action.

Basic Information

Product Name	Dothiepin
CAS No.	113-53-1
Molecular Formula	C₁₉H₂₁NS
Molecular Weight	295.44 g/mol
Synonyms	Dosulepin; Dothiepin Hydrochloride (protonated form); Prothiaden; 11-(3-Dimethylaminopropylidene)-6H-dibenzo[b,e]thiepin; 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine; NSC 106977
EINECS	204-028-7

Quality Control

Our Dothiepin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes comprehensive analytical testing, including identification, assay, and impurity profiling, to meet the stringent requirements of pharmaceutical applications. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.