Description

Agomelatine CAS NO 138112-76-2 is a synthetic melatonin receptor agonist and a selective serotonin 5-HT2C receptor antagonist. This dual mechanism of action makes it a critical active pharmaceutical ingredient (API) for the treatment of major depressive disorder. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development and production of advanced neuropsychiatric therapeutics. Its unique pharmacological profile offers a differentiated approach to managing depression with a favorable side-effect spectrum.

Application

• Primary Active Pharmaceutical Ingredient (API) in antidepressant formulations.
• Reference standard for analytical method development and validation in quality control laboratories.
• Key intermediate in advanced pharmaceutical research for novel CNS (Central Nervous System) drug candidates.
• Biochemical research tool for studying melatonin (MT1 and MT2) and serotonin (5-HT2C) receptor pathways.
• Manufacturing of finished dosage forms, such as film-coated tablets, for clinical and commercial use.
• Process development and scale-up activities within GMP (Good Manufacturing Practice) facilities.

Basic Information

Product Name	Agomelatine
CAS No.	138112-76-2
Molecular Formula	C15H17NO2
Molecular Weight	243.30 g/mol
Synonyms	N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide; S 20098; S-20098; Valdoxan; Thymanax; Melitor; Agomelatine; (N-[2-(7-Methoxynaphthalen-1-yl)ethyl]acetamide)
EINECS	Contact for details

Quality Control

Our Agomelatine is manufactured under strict quality systems to meet the rigorous standards required for pharmaceutical actives. Each batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, to ensure compliance with pharmacopeial specifications (e.g., EP, USP). A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in original packaging until use to prevent degradation.

Specification

Item	Specification
Appearance	White to almost white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity: ≤ 0.10% Total impurities: ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.