Description

5-(3-Dimethylaminopropyl)-10,11-Dihydro-5H-Dibenzo[A,D]Cyclohepten-5-Ol is a tricyclic tertiary amino alcohol with a complex dibenzocycloheptene structure, serving as a critical advanced pharmaceutical intermediate. Its primary value lies in its role as a key synthetic precursor for the production of tricyclic antidepressant drugs and other active pharmaceutical ingredients (APIs) targeting the central nervous system. This compound is essential for pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of complex therapeutic molecules.

Application

• Pharmaceutical Intermediate: Primary building block for the synthesis of tricyclic antidepressant agents such as amitriptyline and nortriptyline.
• Neurological Research: Used in the research and development of novel psychoactive compounds and neuropharmacological studies.
• API Synthesis: Key precursor in multi-step synthetic routes for producing high-value, complex active pharmaceutical ingredients (APIs).
• Fine Chemical Manufacturing: Employed in custom synthesis and scale-up processes for specialty chemicals with specific stereochemical requirements.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical production.
• Chemical Biology: Utilized in the development of molecular probes for studying neurotransmitter reuptake mechanisms.

Basic Information

Product Name	5-(3-Dimethylaminopropyl)-10,11-Dihydro-5H-Dibenzo[A,D]Cyclohepten-5-Ol
CAS No.	1159-03-1
Molecular Formula	C20H25NO
Molecular Weight	295.42 g/mol
Synonyms	10,11-Dihydro-5-(3-(dimethylamino)propyl)-5H-dibenzo[a,d]cyclohepten-5-ol; NSC 108161; 5H-Dibenzo[a,d]cyclohepten-5-ol, 10,11-dihydro-5-[3-(dimethylamino)propyl]-; Amitriptyline Intermediate; 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ol; Nortriptyline Precursor
EINECS	Contact for details

Quality Control

Our 5-(3-Dimethylaminopropyl)-10,11-Dihydro-5H-Dibenzo[A,D]Cyclohepten-5-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality protocols are designed to meet the stringent requirements of cGMP (current Good Manufacturing Practice) for advanced intermediates, supporting our clients' regulatory filings with global health authorities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.