Description

2-Chloro-4,6-Bis(trifluoromethyl)benzoic acid is a highly functionalized benzoic acid derivative, distinguished by its electron-withdrawing chloro and trifluoromethyl substituents. This unique structure makes it a valuable and versatile advanced pharmaceutical intermediate and a key building block for the synthesis of complex organic molecules. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Serves as a key building block for developing new-generation herbicides and fungicides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis, enabling novel synthetic transformations.
• Material Science Research: Employed in the synthesis of monomers for advanced polymers with specific thermal, chemical, or surface properties.
• Fluorinated Compound Library: An essential reagent for medicinal chemistry and discovery chemistry programs focused on creating fluorinated compound libraries to explore structure-activity relationships.
• Custom Synthesis and Contract Manufacturing: A starting material for custom synthesis projects requiring the introduction of a highly substituted, electron-deficient benzoic acid moiety.

Basic Information

Product Name	2-Chloro-4,6-Bis(trifluoromethyl)benzoic Acid
CAS No.	916420-47-8
Molecular Formula	C9H3ClF6O2
Molecular Weight	292.56 g/mol
Synonyms	2-Chloro-α,α,α,α',α',α'-hexafluoro-4,6-xylene-α-carboxylic Acid; Benzoic acid, 2-chloro-4,6-bis(trifluoromethyl)-; 2-Chloro-4,6-di(trifluoromethyl)benzoic Acid; 4,6-Bis(trifluoromethyl)-2-chlorobenzoic Acid; 2-Chloro-4,6-bis(trifluoromethyl)benzoic acid; 916420-47-8
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-4,6-Bis(trifluoromethyl)benzoic acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support our clients' regulatory needs and can supply material suitable for use in cGMP environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its chemical nature, keep away from strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.