Description

3-(2,2,2-Trifluoroethylthio)-Benzeneboronic Acid is a specialized organoboronic acid derivative, a crucial building block in modern synthetic chemistry. Its core value lies in the unique combination of the boronic acid functional group, enabling Suzuki-Miyaura cross-coupling reactions, and the electron-withdrawing trifluoroethylthio moiety, which can significantly influence the reactivity and physicochemical properties of target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing novel active ingredients, particularly those requiring the introduction of fluorinated aromatic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex aromatic and heteroaromatic structures via palladium-catalyzed cross-coupling in the research and development of new drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides where the fluorine-containing group enhances biological activity, stability, and lipophilicity.
• Material Science Research: Serves as a monomer or functionalization agent in the synthesis of novel organic electronic materials, such as polymers for OLEDs or conductive films.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated ligands for catalysis or as a precursor for boron-containing molecular frameworks.
• Chemical Biology Probes: Utilized in the design and synthesis of activity-based probes or diagnostic agents that target specific biological pathways.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector with tailored, high-value intermediates.

Basic Information

Product Name	3-(2,2,2-Trifluoroethylthio)-Benzeneboronic Acid
CAS No.	915402-00-5
Molecular Formula	C8H8BF3O2S
Molecular Weight	236.02 g/mol
Synonyms	[3-(2,2,2-Trifluoroethylsulfanyl)phenyl]boronic acid; Benzeneboronic acid, 3-[(2,2,2-trifluoroethyl)thio]-; 3-(Trifluoroethylthio)phenylboronic acid; 3-TFET-BA; (3-((2,2,2-Trifluoroethyl)thio)phenyl)boronic acid; 3-(2,2,2-Trifluoroethylmercapto)benzeneboronic Acid
EINECS	Contact for details

Quality Control

Our production of 3-(2,2,2-Trifluoroethylthio)-Benzeneboronic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assay and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, identity, and impurity profiles to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere to minimize exposure to moisture and oxygen, which can affect stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.