Description

Benzeneacetic Acid, α,2-Difluoro- is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound is valued for its ability to introduce both a difluoromethyl and a carboxylic acid functional group into target molecules, enabling precise modulation of their physicochemical and biological properties. It is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a difluoromethylphenyl moiety to enhance metabolic stability, lipophilicity, or binding affinity.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, where the difluoroacetic acid group can improve bioactivity and environmental profile.
• Liquid Crystal & Material Science: Serves as a precursor for fluorinated monomers and ligands used in the creation of advanced polymers, liquid crystals, and electronic materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, esterifications, and amide couplings to construct complex, fluorinated molecular architectures for various R&D applications.

Basic Information

Product Name	Benzeneacetic Acid, α,2-Difluoro-
CAS No.	915070-97-2
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	2,2-Difluoro-2-phenylacetic acid; α,α-Difluorophenylacetic acid; (2,2-Difluoro-2-phenylethanoic acid); 2-Phenyl-2,2-difluoroacetic acid; Difluorophenylacetic Acid; DFPA; NSC 405124; Benzeneacetic acid, α,α-difluoro-
EINECS	Contact for details

Quality Control

Every batch of Benzeneacetic Acid, α,2-Difluoro- is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up activities. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.