Description

2-(3,4-Difluorophenyl)-2,2-Difluoroacetic Acid is a high-purity fluorinated aromatic acetic acid derivative, serving as a critical building block in advanced organic synthesis. Its unique difluorophenyl and gem-difluoroacetate structure makes it a valuable precursor for creating complex molecules with enhanced metabolic stability and bioavailability. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitors and CNS-targeted drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms improve lipophilicity and biological activity.
• Material Science: Serves as a monomer or modifier in the synthesis of specialty polymers and liquid crystals with specific optical or electronic properties.
• Organic Synthesis Building Block: A versatile reagent for introducing the difluorophenylacetic acid moiety into more complex molecular architectures via coupling reactions.
• Fluorine Chemistry Research: Valuable compound for academic and industrial research exploring the effects of fluorine substitution on chemical reactivity and physical properties.

Basic Information

Product Name	2-(3,4-Difluorophenyl)-2,2-Difluoroacetic Acid
CAS No.	915030-48-7
Molecular Formula	C8H4F4O2
Molecular Weight	208.11 g/mol
Synonyms	2,2-Difluoro-2-(3,4-difluorophenyl)acetic Acid; α,α-Difluoro-3,4-difluorophenylacetic Acid; 3,4-Difluoro-α,α-difluorophenylacetic Acid; (3,4-Difluorophenyl)difluoroacetic Acid; 915030-48-7; Difluorophenyl Difluoroacetate Derivative
EINECS	Contact for details

Quality Control

Every batch of 2-(3,4-Difluorophenyl)-2,2-Difluoroacetic Acid is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent, keep away from heat, sparks, open flames, and incompatible materials such as strong bases and oxidizing agents. Keep the container tightly sealed when not in use to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.